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Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

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dc.contributor.authorGonzalez, Maria Camila
dc.contributor.authorTovar‐Rios, Diego Alejandro
dc.contributor.authorAlves, Guido
dc.contributor.authorDalen, Ingvild
dc.contributor.authorWilliams‐Gray, Caroline H.
dc.contributor.authorCamacho, Marta
dc.contributor.authorForsgren, Lars
dc.contributor.authorBäckström, David
dc.contributor.authorLawson, Rachael A.
dc.contributor.authorMacleod, Angus D.
dc.contributor.authorCounsell, Carl E.
dc.contributor.authorPaquet, Claire
dc.contributor.authorDeLena, Carlo
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorPilotto, Andrea
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorBlanc, Frédéric
dc.contributor.authorFalup‐Pecurariu, Cristian
dc.contributor.authorLewis, Simon J.G.
dc.contributor.authorRejdak, Konrad
dc.contributor.authorPapuc, Ewa
dc.contributor.authorHort, Jakub
dc.contributor.authorNedelska, Zuzana
dc.contributor.authorO'Brien, John
dc.contributor.authorBonanni, Laura
dc.contributor.authorMarquié, Marta
dc.contributor.authorBoada, Mercè
dc.contributor.authorPytel, Vanesa
dc.contributor.authorAbdelnour, Carla
dc.contributor.authorAlcolea, Daniel
dc.contributor.authorBeyer, Katrin
dc.contributor.authorTysnes, Ole‐Bjørn
dc.contributor.authorAarsland, Dag
dc.contributor.authorMaple‐Grødem, Jodi
dc.date.accessioned2025-10-01T20:03:05Z
dc.date.issued2023-05-05
dc.description.abstractABSTRACT Background There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E‐DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods The annual change in MMSE and MDS‐UPDRS part III was estimated using linear mixed regression models in patients with at least one follow‐up (DLB n = 837 and PDD n = 157). Results When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS‐UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.
dc.identifier.doi10.1002/mdc3.13752
dc.identifier.issn2330-1619
dc.identifier.issn2330-1619
dc.identifier.urihttps://repository.unitbv.ro/handle/123456789/2772
dc.publisherWiley
dc.relation.ispartofMovement Disorders Clinical Practice
dc.titleCognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.volume10

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