Universitatea Transilvania din Brasov

Open Access Repository

Arhiva digitală instituțională ce oferă acces deschis la rezultatele cercetării științifice și la resurse pentru educație: teze de doctorat, articole științifice, baze de date, studii, rapoarte, lucrări prezentate la conferințe și alte documente relevante.

Universitatea Transilvania din Brasov Open Access Repository

Arhiva digitală instituțională ce oferă acces deschis la rezultatele cercetării științifice și la resurse pentru educație: teze de doctorat, articole științifice, baze de date, studii, rapoarte, lucrări prezentate la conferințe și alte documente relevante.

Recent Submissions

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    Enhancement of the Solubility and Dissolution Profile of Rivaroxaban by the Antisolvent Precipitation Technique: A Promising Approach
    (MDPI AG, 2026-05-05) Benga, Claudia Maria; Ozon, Emma Adriana; Musuc, Adina Magdalena; Anuța, Valentina; Sârbu, Iulian; Surdu, Vasile Adrian; Teodorescu, Florina; Rusu, Adriana; Popa, Lăcrămioara; Ghica, Mihaela Violeta; Chandak, Abhay; Pîrvu, Cristina Elena Dinu
    The development of new pharmaceutical forms with high solubility and enhanced bioavailability currently represents a significant challenge in the pharmaceutical industry. Currently, methods are still being explored to improve the oral bioavailability of Rivaroxaban, estimated to be 60%, due to its low solubility. To address these challenges, this study uses the antisolvent precipitation method to obtain three nanosuspensions of rivaroxaban (RIV), using Poloxamer 188 (P188) and hydroxypropyl methylcellulose (HPMC) by varying their concentrations (1:1:1, 1:1:2, and 1:2:1 molar ratios). The RIV nanosuspensions were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The antisolvent precipitation method led to the successful formulation of the three RIV nanosuspensions. Afterward, the formulated tablets containing dry RIV nanosuspensions were pharmaceutically characterized. RIV-P188-HPMC (1:1:1) and RIV-P188-HPMC (1:2:1) dry nanosuspensions demonstrated a uniform flow, and they were subsequently analyzed to establish the in vitro dissolution profile. The nanosuspension formulation with a higher content of P188 showed superior performance. Overall‚ the results of this study show that the antisolvent precipitation method in the presence of different amounts of HPMC and P188 is very efficient in increasing the dissolution rate of rivaroxaban to achieve its better efficiency.
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    Functional Biomechanical Analysis of Javelin Throw Technique in Junior Athletes
    (Journal of Functional Morphology and Kinesiology, 2026-03-31) Cuciorovschi, Ligia; Brus, Denisa Iulia; Teriș, Ștefan; Enoiu, Răzvan Sandu
    Background: Javelin throw performance is strongly influenced by the coordination of the kinetic chain and by key biomechanical parameters related to technique execution. Understanding the functional biomechanical characteristics of javelin throw technique in junior athletes is essential for optimizing performance. Methods: This study investigated the biomechanical characteristics of javelin throw technique in junior athletes using an applied motion analysis approach. Kinematic, spatiotemporal, and performance-related variables were assessed during throwing trials at two evaluation time points, before and after a structured biomechanics-informed training period, using motion analysis tools and wearable measurement systems as instruments. Results: Significant pre–post changes were observed in technique-related variables (release angle and coordination indices) and in performance outcomes (throwing distance and ball throw speed). Conclusions: These findings highlight the functional relationships between biomechanical technique variables and javelin throw outcomes in junior athletes and suggest that field-based biomechanical monitoring can be useful for tracking technique-related changes during structured training in junior throwers.
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    A Review of Seatbelt Technologies and Their Role in Vehicle Safety
    (Applied Sciences Basel, MDPI, 2025-05-09) Soica Adrian, Gheorghe Carmen
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